Once a vaccine goes into your arm, your blood flow increases and immune cells rush to the scene. JAMA (2021) 326:204354. In this study, a higher frequency of adverse events reported by participants in the mixed-manufacturer vaccination group. (D) Kinetics of B-lymphocyte count according to age. COVID-19; SARS-CoV-2; adverse reaction; neuropathy; side effect; vaccination. Amyloid -related angiitis of the central nervous system occurring after COVID-19 vaccination: A case report. One of the most unusual and serious side-effects of the COVID-19 vaccine jab, which has been reported from various corners is Blood clotting. Hermel DJ, Spierling Bagsic SR, Costantini CL, Mason JR, Gahvari ZJ, Saven A. ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients. 8 A total of 3 643 918 persons were enrolled in v-safe and completed at least 1 health survey within 7 days following their first vaccine dose; 1 920 872 v-safe participants reported receiving a second vaccine dose and completed at . The observations made in the "Study of blood group analysis and its correlation with lymphopenia in Covid- 19 infected people" were carried during the first wave of cases for two months in a retrospective manner. Dr. Susan R. Bailey, an allergist, immunologist and president of the American Medical Association, said side effects develop because your immune system is reacting to the vaccine. METHODOLOGY A cross-sectional study was carried out, in which . A previous study in the journal Blood Advances from 2020 also affirmed this research, adding that people with Type O blood seem to be more protected from Covid. Read on to find out if you're safe, and for more risky behavior to be aware of, know that It Only Takes This Long to Get COVID in a Room With Someone Who Has It. He had personal struggles during a life-changing year. SARS-CoV-2 and adverse reactions to SARS-CoV-2 vaccinations show a tropism for neuronal structures and tissues. The log-transformed level of interferon-gamma, CD4+ T-cell count, B-lymphocyte count, and IL-6 level were used as independent variables. Epub 2021 Aug 28. O is the most common blood type in the U.S.: 37 percent of white Americans fall into this category, according to the American Red Cross, with the numbers rising to 47 percent among African-Americans, 53 percent among Latinx-Americans, and 39 percent of Asian-Americans. Figure1 Study profile. If you are hesitant because of the possibility of COVID vaccine side effects, the good news is, the risk of a severe reaction is low andDr. We excluded 14 (2.4%) participants from the regression analysis and mixed model analysis due to missing data: 8 who withdrew their consent, 2 who did not answer age-related questions, 2 who missed a follow-up visit, and 2 who did not provide blood samples (Figure1). Opens in a new tab or window, Visit us on Facebook. FOIA Lancet Infect Dis (2022) 22:47382. Of the 107,796 individuals tested for COVID-19, 11,468 patients tested positive. When a vaccine is injected, the body's immune response jumps into action, responding to the presence of a foreign entity. Unfolding the determinants of COVID-19 vaccine acceptance in China. Li JX, Wu SP, Guo XL, Tang R, Huang BY, Chen XQ, et al. Wang Z, Liu H, Li Y, Luo X, Yang N, Lv M, et al. Nat Commun (2021) 12:1162. doi:10.1038/s41467-021-21444-5, 22. Pour en savoir plus sur la faon dont nous utilisons vos donnes personnelles, veuillez consulter notre politique relative la vie prive et notre politique en matire de cookies. On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group . While Anderson and colleagues noted their sample was mostly white, with a minority contribution from other ethnicities, they added their results were similar when restricted to white race alone. First there is a reaction in the arm where you are injected - think swelling and soreness - as the immune system swings into gear. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. The levels of cellular immune molecules, such as IFN- and CD4+ T-lymphocytes, reflect the levels of effector molecules involved in the humoral immune response, such as memory B cells and neutralizing antibodies (26). This content includes information from experts in their field and is fact-checked to ensure accuracy. This work was supported by the Henan Provincial Key Programs in Science and Technology [grant numbers 202102310355 and 182102311241] to YY and WY, and the Joint Program of Medical Science and Technology Research of Henan Province [grant numbers SB 201903018, LHGJ 20190611, and LHGJ 20200016] to YY and BW. Additionally, "Rh had a lower [adjusted relative risk] of severe COVID-19 illness or death.". Just because youre Type O doesnt mean youre in the clear. The two tubes with the EDTA anticoagulant were used to determine lymphocyte subsets with or without antigen-stimulated SARS-CoV-2 spike peptides, and the two tubes without the EDTA anticoagulant were used to determine neutralizing antibodies against SARS-CoV-2 and cytokines with or without antigen-stimulated SARS-CoV-2 spike peptides. The results were notable: Adjusting for demographics and co-morbidities, the risk for a COVID-19 diagnosis was 12 percent lower for people with type O blood and the risk for severe COVID-19 or death was 13 percent lower, compared to those with A, AB, or B blood types. A few side effects are serious, but rare. The levels of neutralizing antibodies and IFN- were higher in medical staff 240 days after vaccination than in workers. In conclusion, safety concerns against SARS-CoV-2 vaccines are backed by an increasing number of studies reporting neurological side effects. 2021 John Wiley & Sons A/S. Data were calculated based on a linear mixed-effects model adjusted for vaccine manufacturer, sex, age, blood type, occupation, and body mass index (BMI). This may explain why individuals with blood type A were more susceptible to SARS-CoV-2 infection than those with other blood types. "There's a fairly decent amount of existing literature beyond SARS-CoV-2" that certain blood types can play a role in disease risk and severity, says Joel Ray, M.D., a clinician scientist and professor at St. Michael's . Lau YL, Fan Leung T, Sirvan Cetin B, Cagri Dinleyici E, Huang LM, Halperin SA, et al. Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. We know the Covid virus damages the lining of your blood vessels. Diarrhea. This unusual clotting may cause different complications, including organ damage, heart attack and stroke. Factors that influence humoral and cellular immune responses were defined within 240 days in individuals vaccinated with an inactivated Chinese vaccine. That's why people are observed for at least 15 minutes after receiving the vaccine with epinephrine at the ready. Vous pouvez modifier vos choix tout moment en cliquant sur le lien Tableau de bord sur la vie prive prsent sur nos sites et dans nos applications. Opens in a new tab or window. IntroductionIn China, the long-term immunogenicity and adverse effects of inactivated vaccines produced by different or the same manufacturer remain unclear. Also, if possible, get some rest. Therefore, we could not determine the level of neutralizing antibodies against viruses that cause breakthrough infection or severe infection. A retrospective analysis of clinically confirmed long post-COVID vaccination syndrome. Cell Res (2022) 32:1036. O and Rh-negative blood types may already have COVID-19 antibodies. This site needs JavaScript to work properly. Finally, individuals with certain occupations, including workers, especially older individuals and men, had low levels of antibodies and had weakened cellular immune responses following the second dose compared to their counterparts, suggesting that a longer gap between vaccine doses, which is a strategy in effect in some countries, should be re-evaluated, especially for more susceptible populations. doi:10.1016/S0140-6736(22)00094-0, 7. (BE) Kinetics of neutralizing antibodies according to (B) vaccination type, (C) age, (D) occupation, and (E) sex. navigator.sendBeacon('https://www.google-analytics.com/collect', payload); Gao GF. doi:10.1056/NEJMoa2027187, Keywords: cellular immune response, COVID-19, inactive vaccine, kinetics, neutralizing antibody, Citation: Yuan Y, Xu J, Ma B, Chen G, Wang Z, Wang S, Jing N, Zhang J, Wang B, Yan W, Zhang Q, Zhao Q and Li Y (2023) Characteristics of humoral and cellular responses to coronavirus disease 2019 (COVID-19) inactivated vaccine in central China: A prospective, multicenter, longitudinal study. So it follows that the response may be most intense around the source of the intruder: a needle in the arm. Blood type O seems to have the lowest risk. Then, a study published in the New England Journal of Medicine confirmed the idea with a peer-reviewed study: Folks with Type A blood were 45 percent more likely to become infected with Covid than those with other blood types, while those with Type O were 35 percent less likely. Wheatley AK, Juno JA, Wang JJ, Selva KJ, Reynaldi A, Tan HX, et al. Participants with documented reverse transcription-polymerase chain reaction-confirmed COVID-19 or those who had been vaccinated with any other vaccine (e.g., influenza or others) or booster vaccine since the primary dose were excluded. Blood type doesnt affect much in our daily lives. Fujigaki H, Yamamoto Y, Koseki T, Banno S, Ando T, Ito H, et al. These include: chills fatigue fever headache muscle pain nausea pain at the injection site redness at the. All participants provided their informed consent in writing before enrollment. SARSCoV2 vaccines are not free of neurological side effects. It's normal to experience side effects after the vaccine. Clinics (Sao Paulo). But theres another interesting layer to a potential protective element in Type O blood: something called von Willebrand factor, which is a glycoprotein in charge of repairing damage to blood vessels by prompting your blood to clot. A total of 1,350 serum samples were collected from 595 participants (Figure1), of whom 457 (76.8%) were medical staff and 138 (23.2%) were workers of the Henan Electric Power Exploration Company in central China. A higher IL-6 level was associated with older age, mixed-manufacturer vaccinations, intervals of less than 40 days between two doses of vaccination, and medical staff. The number of participants was relatively small, and at the time of the clinical study design, the administrators did not advocate the administration of vaccines from different manufacturers for separate doses. Shutterstock The researchers at St. Michael's Hospital in Toronto, Canada, examined the test results of 225,556 Canadians who had been tested for COVID-19 between Jan. 15 and Jun. In contrast, we observed a decrease in the B-lymphocyte count and IL-6 level on days 1 to 240 in participants stimulated with the SARS-CoV-2 S antigen (B = 0.004, 95% CI 0.005 to 0.003; p = 0.008 and B = 0.004, 95% CI 0.006 to 0.002, p = 0.001, respectively; Tables5, 6; Figures3A, G). doi:10.1016/S0140-6736(21)01420-3, 15. At 240 days after vaccination, the GMC of neutralizing antibodies in the mixed-manufacturer vaccination group decreased to 8.5 IU/mL, which was less than the decrease detected in the same-manufacturer vaccination group (20.5 IU/mL) (p < 0.001). Blood clots with low platelets Capillary leak syndrome Guillain-Barr syndrome (GBS) Ongoing monitoring of side effects and reactions As the COVID-19 vaccine rollout continues across Canada, safety monitoring is ongoing. -, Finsterer J, Scorza FA. The positive rate of neutralizing antibodies peaked at 97.7% at 6090 days, decreased, and stabilized at 82.9% at 181240 days post-vaccination. Shes most passionate about hiking, traveling, mindfulness, cooking, and really, really good coffee. Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19. The platelets, which normally promote wound healing, end up clumping and causing blood. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: A preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial. ABO blood typing was performed using a test-tube method according to the manufacturers protocol (Chengdu Xiehe Ltd., Co., Chengdu, China). BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: A prospective, single-centre, longitudinal cohort study in health-care workers. PMC Safety definitions and a list of solicited adverse events were defined as previously described (16, 17).